In the ancient and medieval worlds, many more people were physically and mentally challenged than there are in the United States, or practically anywhere, today. There were no operations to fix club feet, or cleft palates, or heart murmurs. There were no antidepressants or antipsychotics for people who heard voices, or any hospitals for them to go to. When people broke bones or dislocated shoulders, they often were not set right and healed wrong, so that you lost the use of your arm or leg. When children didn't get enough milk, they got rickets and their legs would be weak and bent, so they couldn't walk well. Eye infections, with no antibiotics, often left people blind in one or both eyes. And even if you were only near-sighted, there were no glasses to help you see.
People's attitudes toward physically and mentally challenged people were also very different then. A lot of people thought that some kinds of physical or mental differences brought you closer to the gods. Blind people, especially blind children, were often thought to know what the gods (or what God) wanted. Epileptics were also thought to be close to the gods. People who heard voices, like Joan of Arc, often became important religious leaders. Many challenged people supported their families by prophecy.
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On the other hand, differences that you could see, like bent legs or club feet, sometimes people thought these meant that the gods didn't like you. The Greeks, especially, thought that the gods liked bodies to be perfect. Because of this, sometimes people exposed their babies if their bodies weren't just right, and sometimes people were cruel to these children as they were growing up.
To find out more about challenged people in the ancient world, check out these books from Amazon or from your local library: